Lig3^tm1.1Pmc
Targeted Allele Detail

Summary

• Symbol: Lig3^tm1.1Pmc
• Name: ligase III, DNA, ATP-dependent; targeted mutation 1.1, Peter J McKinnon
• MGI ID: MGI:4946931
• Synonyms: Lig3^c, Lig3^LoxP
• Gene: Lig3 Location: Chr11:82671977-82695100 bp, + strand Genetic Position: Chr11, 50.23 cM, cytoband B5
• Alliance: Lig3^tm1.1Pmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170077
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted downstream of exon 5 and upstream of exon 15. An FRT-flanked neo cassette was removed by flp-mediated recombination. (J:170077)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lig3 Mutation: 41 strains or lines available

References

• Original: J:170077 Gao Y, et al., DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair. Nature. 2011 Mar 10;471(7337):240-4
• All: 2 reference(s)