Calr3^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Calr3^tm1Osb
• Name: calreticulin 3; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:4946941
• Gene: Calr3 Location: Chr8:73178020-73197638 bp, - strand Genetic Position: Chr8, 35.08 cM, cytoband C1
• Alliance: Calr3^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170595
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced most of exons 3 and 4. The absence of protein expression was confirmed by western blot analysis on testis lysates. (J:170595)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Calr3 Mutation: 31 strains or lines available

References

• Original: J:170595 Ikawa M, et al., Calsperin is a testis-specific chaperone required for sperm fertility. J Biol Chem. 2011 Feb 18;286(7):5639-46
• All: 3 reference(s)