Tg(NEFH)398Jpj
Transgene Detail

Summary

• Symbol: Tg(NEFH)398Jpj
• Name: transgene insertion 398, Jean-Pierre Julien
• MGI ID: MGI:4947051
• Synonyms: NF-H⁴⁴
• Transgene: Tg(NEFH)398Jpj Location: unknown
• Alliance: Tg(NEFH)398Jpj page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(NEFH)398Jpj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NEFH (4744)

  Nefh	(MGI:97309)

• Mutation details: The genomic fragments containing the human NEFH gene, flanked by 5'-promoter region and 3' sequences, coding for 44 Lys-Ser-Pro (KSP) phosphorylation sites, was used for the transgene. The total amount of protein detected in cytoskeletal-enriched preparations of the spinal cord corresponds to about two-fold the level detected in normal mice as determined by Coomassie blue after SDS/PAGE. (J:69179)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:69179 Couillard-Despres S, et al., Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9626-30
• All: 1 reference(s)