Enpp7^tm1Rudd
Targeted Allele Detail

Summary

• Symbol: Enpp7^tm1Rudd
• Name: ectonucleotide pyrophosphatase/phosphodiesterase 7; targeted mutation 1, Rui-Don Duan
• MGI ID: MGI:4947121
• Synonyms: alk-SMase knockout
• Gene: Enpp7 Location: Chr11:118879014-118884047 bp, + strand Genetic Position: Chr11, 83.33 cM
• Alliance: Enpp7^tm1Rudd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170667
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. A neo cassette and 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on intestinal extracts. (J:170667)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Enpp7 Mutation: 15 strains or lines available

References

• Original: J:170667 Zhang Y, et al., Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice. J Lipid Res. 2011 Apr;52(4):771-81
• All: 3 reference(s)