Derl2^tm1.2Hpl
Targeted Allele Detail

Summary

• Symbol: Derl2^tm1.2Hpl
• Name: Der1-like domain family, member 2; targeted mutation 1.2, Hidde Ploegh
• MGI ID: MGI:4947129
• Gene: Derl2 Location: Chr11:70898266-70910667 bp, - strand Genetic Position: Chr11, 43.21 cM
• Alliance: Derl2^tm1.2Hpl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170650
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 4 through 6. The absence of protein expression was confirmed by western blot analysis on colon, pancreas, lymph node, spleen, thymus, lungs, liver, and lung extracts. (J:170650)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Derl2 Mutation: 18 strains or lines available

References

• Original: J:170650 Dougan SK, et al., Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol. 2011 Mar;31(6):1145-59
• All: 1 reference(s)