Rho^tm1.1Kpal
Targeted Allele Detail

Summary

• Symbol: Rho^tm1.1Kpal
• Name: rhodopsin; targeted mutation 1.1, Krzysztof Palczewski
• MGI ID: MGI:4947230
• Synonyms: Rho^P23H
• Gene: Rho Location: Chr6:115908709-115916997 bp, + strand Genetic Position: Chr6, 53.72 cM
• Alliance: Rho^tm1.1Kpal page

Retinal degeneration in Rho^tm1.1Kpal/Rho⁺ and Rho^tm1.1Kpal/Rho^tm1.1Kpal mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170648
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted Mutations: Insertion, Single point mutation Mutation details: Nucleotide substitution at codon 23 (CCC to CAC) resulted in the amino acid substitution of proline with histidine (p.Pro23His or p.P23H). An FRT-flanked neo cassette inserted downstream of exon 1 was removed by flp-mediated recombination. (J:170648)

Generation of the Rho^tm1.1Kpal allele

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rho Mutation: 51 strains or lines available

References

• Original: J:170648 Sakami S, et al., Probing Mechanisms of Photoreceptor Degeneration in a New Mouse Model of the Common Form of Autosomal Dominant Retinitis Pigmentosa due to P23H Opsin Mutations. J Biol Chem. 2011 Mar 25;286(12):10551-67
• All: 38 reference(s)