Jup^tm1.2Glr
Targeted Allele Detail

Summary

• Symbol: Jup^tm1.2Glr
• Name: junction plakoglobin; targeted mutation 1.2, Glenn L Radice
• MGI ID: MGI:4947240
• Gene: Jup Location: Chr11:100259784-100288589 bp, - strand Genetic Position: Chr11, 63.47 cM
• Alliance: Jup^tm1.2Glr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170618
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1, and a loxP site and an FRT-flanked neo cassette were introduced into intron 1 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 1 floxed. Cre mediated recombination removed exon 1. Western blot analysis of E12.5 homozygous embryos confirmed the absence of protein expression. (J:170618)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jup Mutation: 162 strains or lines available

References

• Original: J:170618 Li J, et al., Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling. Mol Cell Biol. 2011 Mar;31(6):1134-44
• All: 2 reference(s)