Ptpn6^me-B2
Spontaneous Allele Detail

Summary

• Symbol: Ptpn6^me-B2
• Name: protein tyrosine phosphatase, non-receptor type 6; motheaten B2
• MGI ID: MGI:4947257
• Synonyms: Ptpn6^meB2
• Gene: Ptpn6 Location: Chr6:124697670-124715672 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Ptpn6^me-B2 page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Spontaneous
• Mutation: Viral insertion
• Mutation details: The B2 element (247 bp) was inserted into exon 6 with a 16 bp duplication that results in alternative splicing and amino acid substitution. (J:169850)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn6 Mutation: 49 strains or lines available

References

• Original: J:169850 Nesterovitch AB, et al., Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans. Am J Pathol. 2011 Apr;178(4):1701-14
• All: 1 reference(s)