Rapgef3^tm1Utak
Targeted Allele Detail

Summary

• Symbol: Rapgef3^tm1Utak
• Name: Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1, Utako Yokoyama
• MGI ID: MGI:4947366
• Synonyms: Epac1^-
• Gene: Rapgef3 Location: Chr15:97642651-97665853 bp, - strand Genetic Position: Chr15, 53.74 cM
• Alliance: Rapgef3^tm1Utak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170436
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 and exon 2 were replaced with a floxed neo cassette. The absence of transcript expression was confirmed by northern blot analysis on brain extracts. (J:170436)

Tumor Data

List all tumor models in MMHCdb carrying Rapgef3^tm1Utak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rapgef3 Mutation: 47 strains or lines available

References

• Original: J:170436 Suzuki S, et al., Differential roles of Epac in regulating cell death in neuronal and myocardial cells. J Biol Chem. 2010 Jul 30;285(31):24248-59
• All: 12 reference(s)