Crp^tm1Hjf
Targeted Allele Detail

Summary

• Symbol: Crp^tm1Hjf
• Name: C-reactive protein, pentraxin-related; targeted mutation 1, H J Fehling
• MGI ID: MGI:4947397
• Gene: Crp Location: Chr1:172525623-172527533 bp, + strand Genetic Position: Chr1, 80.13 cM
• Alliance: Crp^tm1Hjf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170409
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced coding sequence in exon 1 and most of exon 2. The absence of protein expression was confirmed by western blot anaylsis on serum. (J:170409)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crp Mutation: 18 strains or lines available

References

• Original: J:170409 Teupser D, et al., No reduction of atherosclerosis in C-reactive protein (CRP)-deficient mice. J Biol Chem. 2011 Feb 25;286(8):6272-9
• All: 2 reference(s)