Topbp1^tm1.1Dsh
Targeted Allele Detail

Summary

• Symbol: Topbp1^tm1.1Dsh
• Name: topoisomerase (DNA) II binding protein 1; targeted mutation 1.1, Deog Su Hwang
• MGI ID: MGI:4947431
• Synonyms: TopBP1^flox
• Gene: Topbp1 Location: Chr9:103182414-103227627 bp, + strand Genetic Position: Chr9, 55.19 cM
• Alliance: Topbp1^tm1.1Dsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170406
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette. (J:170406)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Topbp1 Mutation: 76 strains or lines available

References

• Original: J:170406 Jeon Y, et al., TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells. J Biol Chem. 2011 Feb 18;286(7):5414-22
• All: 3 reference(s)