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Dusp4tm1Plev
Targeted Allele Detail
Summary
Symbol: Dusp4tm1Plev
Name: dual specificity phosphatase 4; targeted mutation 1, Robin Plevin
MGI ID: MGI:4947517
Gene: Dusp4  Location: Chr8:35274451-35287048 bp, + strand  Genetic Position: Chr8, 21.16 cM
Alliance: Dusp4tm1Plev page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170774
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette replaced exons 2, 3, and 4. The absence of protein expression was confirmed by western blot analysis on bone marrow-derived macrophages stimulated with LPS. (J:170774)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dusp4 Mutation:  22 strains or lines available
References
Original:  J:170774 Al-Mutairi MS, et al., MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana. PLoS Pathog. 2010;6(11):e1001192
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory