Kcne3^tm1Gwab
Targeted Allele Detail

Summary

• Symbol: Kcne3^tm1Gwab
• Name: potassium voltage-gated channel, Isk-related subfamily, gene 3; targeted mutation 1, Geoffrey W Abbott
• MGI ID: MGI:4947550
• Gene: Kcne3 Location: Chr7:99825714-99834076 bp, + strand Genetic Position: Chr7, 54.33 cM, cytoband F1
• Alliance: Kcne3^tm1Gwab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170745
• Parent Cell Line: C2J (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced exon 4. The absence of protein expression was confirmed by western blot analysis on colon extracts. (J:170745)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcne3 Mutation: 11 strains or lines available

References

• Original: J:170745 Roepke TK, et al., Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo. FASEB J. 2011 Feb;25(2):727-36
• All: 4 reference(s)