Lrig1^{tm1.1(cre/ERT2)Rjc}
Targeted Allele Detail

Summary

• Symbol: Lrig1^{tm1.1(cre/ERT2)Rjc}
• Name: leucine-rich repeats and immunoglobulin-like domains 1; targeted mutation 1.1, Robert J Coffey
• MGI ID: MGI:4947937
• Synonyms: Lrig1-CreERT2
• Gene: Lrig1 Location: Chr6:94581510-94677139 bp, - strand Genetic Position: Chr6, 43.15 cM
• Alliance: Lrig1^{tm1.1(cre/ERT2)Rjc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186084
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Lrig1^{tm1.1(cre/ERT2)Rjc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lrig1 (MGI:107935)

• Mutation details: The targeting vector used for homologous recombination was generated by BAC recombineering. A tamoxifen-inducible cre (cre/ERT2) sequence, SV40 polyA signal, and an Frt-flanked PGK-neo cassette were targeted to the endogenous ATG site of Lrig1. Chimeras were crossed with Flpe-expressing animals to remove the neo from the germline. (J:186084)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lrig1 (mouse) Summary of all recombinase alleles driven by Lrig1. Comparative matrix view of recombinase activities Alliance mouse Lrig1 gene page

Tumor Data

List all tumor models in MMHCdb carrying Lrig1^{tm1.1(cre/ERT2)Rjc}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrig1 Mutation: 50 strains or lines available

References

• Original: J:186084 Powell AE, et al., The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell. 2012 Mar 30;149(1):146-58
• All: 43 reference(s)