Xirp2^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Xirp2^tm1Itl
• Name: xin actin-binding repeat containing 2; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:4947971
• Synonyms: Xirp2 loxP-neo, Xirp2^tm1Igl
• Gene: Xirp2 Location: Chr2:67276343-67356964 bp, + strand Genetic Position: Chr2, 39.31 cM
• Alliance: Xirp2^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170869
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. A floxed neo cassette was inserted downstream of exon 6. Western blot analysis on hindlimb and cardiac extracts confirmed largely absent protein expression. This allele is hypomorphic. (J:170869)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xirp2 Mutation: 163 strains or lines available

References

• Original: J:170869 McCalmon SA, et al., Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2. Circ Res. 2010 Mar 19;106(5):952-60
• All: 2 reference(s)