Ntrk2^tm1Bxu
Targeted Allele Detail

Summary

• Symbol: Ntrk2^tm1Bxu
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 1, Baoji Xu
• MGI ID: MGI:4947984
• Synonyms: fBneo
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^tm1Bxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170724
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the first coding exon (exon S). An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the first coding exon (exon S). Reduced protein expression was confirmed by western blot analysis on cortex, striatum, and substantia nigra extracts. This is a hypomorphic allele. (J:170724)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:170724 Baydyuk M, et al., Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration. Exp Neurol. 2011 Mar;228(1):118-25
• All: 4 reference(s)