Gpr88^{tm1.1(cre/GFP)Rpa}
Targeted Allele Detail

Summary

• Symbol: Gpr88^{tm1.1(cre/GFP)Rpa}
• Name: G-protein coupled receptor 88; targeted mutation 1.1, Richard D Palmiter
• MGI ID: MGI:4947986
• Synonyms: Gpr88^Cre
• Gene: Gpr88 Location: Chr3:116043304-116047123 bp, - strand Genetic Position: Chr3, 50.23 cM, cytoband G1
• Alliance: Gpr88^{tm1.1(cre/GFP)Rpa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170830
• Parent Cell Line: AK18.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Gpr88^{tm1.1(cre/GFP)Rpa} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gpr88 (MGI:1927653)

• Mutation details: Cre/GFP with a neo cassette was targeted to the first coding exon of Gpr88. The neo selection cassette was then removed by crossing to Gt(ROSA)26Sor^tm1(FLP1)Dym mice. (J:170830, J:193543)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gpr88 (mouse) Summary of all recombinase alleles driven by Gpr88. Alliance mouse Gpr88 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpr88 Mutation: 16 strains or lines available

References

• Original: J:170830 Beutler LR, et al., Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4206-11
• All: 13 reference(s)