Itga8^tm1.1Rdav
Targeted Allele Detail

Summary

• Symbol: Itga8^tm1.1Rdav
• Name: integrin alpha 8; targeted mutation 1.1, Ronald Davis
• MGI ID: MGI:4948106
• Synonyms: f(a8), fA8, f(alpha8), falpha8, floxed alpha8-integrin
• Gene: Itga8 Location: Chr2:12111443-12306733 bp, - strand Genetic Position: Chr2, 9.12 cM
• Alliance: Itga8^tm1.1Rdav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170959
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site just upstream of exon 29, and also insert a loxP-flanked TK-neo cassette about 4kb downstream of the STOP codon in exon 30 of the Itga8 gene (also called integrin alpha 8, alpha8-integrin, or a8-integrin). Cre-mediated recombination removed the TK-neo selection cassette, leaving a single loxP site upstream of exon 29 and a single loxP site downstream of exon 30. (J:170959)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itga8 Mutation: 75 strains or lines available

References

• Original: J:170959 Chan CS, et al., alpha8-integrins are required for hippocampal long-term potentiation but not for hippocampal-dependent learning. Genes Brain Behav. 2010 Jun 1;9(4):402-10
• All: 2 reference(s)