Col1a1^tm1Dab
Targeted Allele Detail

Summary

• Symbol: Col1a1^tm1Dab
• Name: collagen, type I, alpha 1; targeted mutation 1, David A Brenner
• MGI ID: MGI:4948122
• Synonyms: 5'-UTR SL
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^tm1Dab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170561
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted between exon 1 and 2. This insertion is predicted to prevent formation of the 5' UTR stem-loop structure within intron 1. Reduced protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:170561)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 163 strains or lines available

References

• Original: J:170561 Parsons CJ, et al., Mutation of the 5'-untranslated region stem-loop structure inhibits alpha1(I) collagen expression in vivo. J Biol Chem. 2011 Mar 11;286(10):8609-19
• All: 1 reference(s)