Oprm1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm1Lex
• Name: opioid receptor, mu 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:4948248
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170718
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 2 and 3 were disrupted. (J:170718)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 54 strains or lines available

References

• Original: J:170718 Kogel B, et al., The antinociceptive and antihyperalgesic effect of tapentadol is partially retained in OPRM1 (mu-opioid receptor) knockout mice. Neurosci Lett. 2011 Mar 17;491(2):104-7
• All: 1 reference(s)