Cdc14b^tm1.2Pzg
Targeted Allele Detail

Summary

• Symbol: Cdc14b^tm1.2Pzg
• Name: CDC14 cell division cycle 14B; targeted mutation 1.2, Pumin Zhang
• MGI ID: MGI:4948253
• Synonyms: Cdc14b^deltaE2
• Gene: Cdc14b Location: Chr13:64337082-64423104 bp, - strand Genetic Position: Chr13, 33.26 cM
• Alliance: Cdc14b^tm1.2Pzg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170763
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 2 and the neo cassette. RT-PCR confirmed the expression of two truncated transcripts that are not predicted to produce a functional protein. (J:170763)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdc14b Mutation: 38 strains or lines available

References

• Original: J:170763 Wei Z, et al., Early-onset aging and defective DNA damage response in cdc14b-deficient mice. Mol Cell Biol. 2011 Apr;31(7):1470-7
• All: 2 reference(s)