In(2Itga6-Evx2)44Ddu
Targeted Allele Detail

Summary

• Symbol: In(2Itga6-Evx2)44Ddu
• Name: inversion, Chr 2, Denis Duboule 44
• MGI ID: MGI:4948261
• Synonyms: HoxD^{Inv(TgHd11lacNsi-Itga6)}, inv(Nsi-Itgalpha6)
• Gene: In(2Itga6-Evx2)44Ddu Location: Chr2:71617230-74489901 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170557
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Inversion
• In(2Itga6-Evx2)44Ddu involves 67 genes/genome features (Gm25960, Zakit, Gm11084 ...) View all
• Mutation details: Mice with the Itga6^tm1Son allele containing a single loxP site between exons 24 and 26 in cis on chromosome 2 with Evx2/Hoxd13^{tm5.1(Hoxd11/lacZ)Ddu} which also contains a loxP site but in reverse orientation to that in the Itga6 allele were crossed to Hprt^tm1(cre)Mnn mice. Cre expression resulted in inversion of a segment of chromosome 2 containing exon 26 of Itga6 and extending into the intergenic region between Evx2 and the Hoxd cluster. After the inversion, the Evx2/Hoxd13^{tm5.1(Hoxd11/lacZ)Ddu}construct and Evx2 were moved to a more centromeric location away from Hoxd. (J:170557)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any In(2Itga6-Evx2)44Ddu Mutation: 0 strains or lines available

References

• Original: J:170557 Tschopp P, et al., A regulatory 'landscape effect' over the HoxD cluster. Dev Biol. 2011 Mar 15;351(2):288-96
• All: 6 reference(s)