Pkd1l1^rks
Chemically induced Allele Detail

Summary

• Symbol: Pkd1l1^rks
• Name: polycystic kidney disease 1 like 1; rikishi
• MGI ID: MGI:4948351
• Gene: Pkd1l1 Location: Chr11:8782025-8924365 bp, - strand Genetic Position: Chr11, 5.57 cM, cytoband A2
• Alliance: Pkd1l1^rks page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An A to T transition mutation at nucleotide 1232 in exon 8 results in a non-conservative substitution of glycine for aspartic acid at position 411. This mutation occurs in a highly conserved residue in the second PKD domain. In silico modeling predicts this mutation will disrupt the structure of the second PKD domain. (J:170490)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pkd1l1 Mutation: 156 strains or lines available

References

• Original: J:170490 Field S, et al., Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2. Development. 2011 Mar;138(6):1131-42
• All: 2 reference(s)