Map1s^tm1.1Lliu
Targeted Allele Detail

Summary

• Symbol: Map1s^tm1.1Lliu
• Name: microtubule-associated protein 1S; targeted mutation 1.1, Leyuan Liu
• MGI ID: MGI:4948361
• Gene: Map1s Location: Chr8:71358618-71370173 bp, + strand Genetic Position: Chr8, 34.41 cM
• Alliance: Map1s^tm1.1Lliu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170757
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 4 and 5. The absence of protein expression was confirmed by western blot analysis on heart extracts. (J:170757)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map1s Mutation: 37 strains or lines available

References

• Original: J:170757 Xie R, et al., Microtubule-associated Protein 1S (MAP1S) Bridges Autophagic Components with Microtubules and Mitochondria to Affect Autophagosomal Biogenesis and Degradation. J Biol Chem. 2011 Mar 25;286(12):10367-77
• All: 6 reference(s)