Rr117^tm1.1Dje
Targeted Allele Detail

Summary

• Symbol: Rr117^tm1.1Dje
• Name: regulatory region 117; targeted mutation 1.1, Douglas J Epstein
• MGI ID: MGI:4948508
• Synonyms: Shh^deltaSBE1, Shh^tm1.1Dje
• Gene: Rr117 Location: unknown Genetic Position: Chr5, Syntenic
• Alliance: Rr117^tm1.1Dje page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170540
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Rr117^tm1.1Dje involves 1 genes/genome features (Shh) View all
• Mutation details: A loxP site was inserted upstream of the 525 bp Shh brain enhancer 1 (SBE1) in intron 2. In addition, an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted immediately downstream of SBE1. Subsequent cre expression excised both SBE1 and the neo cassette. (J:170540)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr117 Mutation: 0 strains or lines available

References

• Original: J:170540 Jeong Y, et al., Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development. 2011 Feb;138(3):531-41
• All: 1 reference(s)