Keap1^tm1.1Sbis
Targeted Allele Detail

Summary

• Symbol: Keap1^tm1.1Sbis
• Name: kelch-like ECH-associated protein 1; targeted mutation 1.1, Shyam Biswal
• MGI ID: MGI:4948838
• Synonyms: Keap1^flox
• Gene: Keap1 Location: Chr9:21141026-21150628 bp, - strand Genetic Position: Chr9, 7.74 cM, cytoband A3
• Alliance: Keap1^tm1.1Sbis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170960
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT- and loxP-flanked neo cassette was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette, leaving exon 2 and 3 floxed. (J:170960)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Keap1^tm1.1Sbis

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Keap1 Mutation: 36 strains or lines available

References

• Original: J:170960 Blake DJ, et al., Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. Am J Respir Cell Mol Biol. 2010 May;42(5):524-36
• All: 24 reference(s)