Egln1^tm1.1Brei
Targeted Allele Detail

Summary

• Symbol: Egln1^tm1.1Brei
• Name: egl-9 family hypoxia-inducible factor 1; targeted mutation 1.1, George Breier
• MGI ID: MGI:4948909
• Synonyms: PHD2^fl, Phd2^flox
• Gene: Egln1 Location: Chr8:125635326-125676063 bp, - strand Genetic Position: Chr8, 72.86 cM
• Alliance: Egln1^tm1.1Brei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170943
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked lacZ and neomycin cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette, leaving exons 2 and 3 floxed. (J:170943, J:200956)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egln1 Mutation: 22 strains or lines available

References

• Original: J:170943 Holscher M, et al., Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury. J Biol Chem. 2011 Apr 1;286(13):11185-94
• All: 11 reference(s)