Egln1^tm1.2Brei
Targeted Allele Detail

Summary

• Symbol: Egln1^tm1.2Brei
• Name: egl-9 family hypoxia-inducible factor 1; targeted mutation 1.2, George Breier
• MGI ID: MGI:4948912
• Gene: Egln1 Location: Chr8:125635326-125676063 bp, - strand Genetic Position: Chr8, 72.86 cM
• Alliance: Egln1^tm1.2Brei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170943
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 2 and 3. The absence of protein expression was confirmed by western blot analysis on E14.5 heart extracts. (J:170943)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egln1 Mutation: 22 strains or lines available

References

• Original: J:170943 Holscher M, et al., Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury. J Biol Chem. 2011 Apr 1;286(13):11185-94
• All: 1 reference(s)