Map2k7^tm1.1Twad
Targeted Allele Detail

Summary

• Symbol: Map2k7^tm1.1Twad
• Name: mitogen-activated protein kinase kinase 7; targeted mutation 1.1, Teiji Wada
• MGI ID: MGI:4948950
• Synonyms: Map2k7^fl, Mkk7^fl
• Gene: Map2k7 Location: Chr8:4288740-4297897 bp, + strand Genetic Position: Chr8, 1.99 cM, cytoband A1.1
• Alliance: Map2k7^tm1.1Twad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170904
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT- and loxP-flanked neo cassette was inserted downstream of exon 10. Flp-mediated recombination removed the neo cassette, leaving exons 3 through 10 floxed. (J:170904)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map2k7 Mutation: 20 strains or lines available

References

• Original: J:170904 Schramek D, et al., The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet. 2011 Mar;43(3):212-9
• All: 5 reference(s)