Map2k7^tm1.1Twad
Targeted Allele Detail

Summary

• Symbol: Map2k7^tm1.1Twad
• Name: mitogen-activated protein kinase kinase 7; targeted mutation 1.1, Teiji Wada
• MGI ID: MGI:4948950
• Synonyms: Map2k7^fl, Mkk7^fl
• Gene: Map2k7 Location: Chr8:4288740-4297897 bp, + strand Genetic Position: Chr8, 1.99 cM, cytoband A1.1
• Alliance: Map2k7^tm1.1Twad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170904
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT- and loxP-flanked neo cassette was inserted downstream of exon 10. Flp-mediated recombination removed the neo cassette, leaving exons 3 through 10 floxed. (J:170904)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Map2k7^tm1.1Twad/Map2k7^tm1.1Twad	B6.Cg-Map2k7^tm1.1Twad
cn2	Kras^tm4Tyj/Kras^+ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad	B6.Cg-Kras^tm4Tyj Map2k7^tm1.1Twad/Map2k7^tm1.2Twad
cn3	Kras^tm4Tyj/Kras^+ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6
cn4	Kras^tm4Tyj/Kras^+ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(Trp53)bSrn/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
cn5	Map2k7^tm1.1Twad/Map2k7^tm1.1Twad Tg(KRT5-cre)1Tak/0	involves: 129P2/OlaHsd * C3H * C57BL/6
cn6	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0 Tg(MMTV-Erbb2)1Pv/0	involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N
cn7	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0	involves: 129P2/OlaHsd * C57BL/6 * FVB

Phenotypes:

Affected Systems	hm1	cn2	cn3	cn4	cn5	cn6		cn7
show or hide all annotated terms Sex:
cellular		√
abnormal DNA repair		√
endocrine/exocrine glands						√	√
increased mammary gland tumor incidence						√	√
increased mammary adenocarcinoma incidence						√	√
mammary gland hyperplasia						√
homeostasis/metabolism		√
abnormal DNA repair		√
integument						√	√
increased mammary gland tumor incidence						√	√
increased mammary adenocarcinoma incidence						√	√
mammary gland hyperplasia						√
mortality/aging		√				√	√
premature death		√				√	√
neoplasm		√	√	N		√	√
neoplasm				N
increased mammary gland tumor incidence						√	√
increased mammary adenocarcinoma incidence						√	√
increased lung tumor incidence		√	√
increased lung adenocarcinoma incidence		√	√
reproductive system								N
reproductive system phenotype								N
respiratory system		√	√
increased lung tumor incidence		√	√
increased lung adenocarcinoma incidence		√	√
vision/eye					√
eyelids open at birth					√
normal phenotype	√
no abnormal phenotype detected	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map2k7 Mutation: 20 strains or lines available

References

• Original: J:170904 Schramek D, et al., The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet. 2011 Mar;43(3):212-9
• All: 5 reference(s)