Map2k7^tm1.2Twad
Targeted Allele Detail

Summary

• Symbol: Map2k7^tm1.2Twad
• Name: mitogen-activated protein kinase kinase 7; targeted mutation 1.2, Teiji Wada
• MGI ID: MGI:4948951
• Synonyms: Map2k7^delta
• Gene: Map2k7 Location: Chr8:4288740-4297897 bp, + strand Genetic Position: Chr8, 1.99 cM, cytoband A1.1
• Alliance: Map2k7^tm1.2Twad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170904
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cre-mediated recombination removed exons 3 through 10. (J:170904)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Kras^tm4Tyj/Kras^+ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad	B6.Cg-Kras^tm4Tyj Map2k7^tm1.1Twad/Map2k7^tm1.2Twad
cn2	Kras^tm4Tyj/Kras^+ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6
cn3	Kras^tm4Tyj/Kras^+ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(Trp53)bSrn/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
cn4	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0 Tg(MMTV-Erbb2)1Pv/0	involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N
cn5	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0	involves: 129P2/OlaHsd * C57BL/6 * FVB

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4		cn5
show or hide all annotated terms Sex:
cellular	√
abnormal DNA repair	√
endocrine/exocrine glands				√	√
increased mammary gland tumor incidence				√	√
increased mammary adenocarcinoma incidence				√	√
mammary gland hyperplasia				√
homeostasis/metabolism	√
abnormal DNA repair	√
integument				√	√
increased mammary gland tumor incidence				√	√
increased mammary adenocarcinoma incidence				√	√
mammary gland hyperplasia				√
mortality/aging	√			√	√
premature death	√			√	√
neoplasm	√	√	N	√	√
neoplasm			N
increased mammary gland tumor incidence				√	√
increased mammary adenocarcinoma incidence				√	√
increased lung tumor incidence	√	√
increased lung adenocarcinoma incidence	√	√
reproductive system						N
reproductive system phenotype						N
respiratory system	√	√
increased lung tumor incidence	√	√
increased lung adenocarcinoma incidence	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map2k7 Mutation: 20 strains or lines available

References

• Original: J:170904 Schramek D, et al., The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet. 2011 Mar;43(3):212-9
• All: 1 reference(s)