Tg(Trp53)bSrn
Transgene Detail

Summary

• Symbol: Tg(Trp53)bSrn
• Name: transgene insertion b, Manuel Serrano
• MGI ID: MGI:4948957
• Synonyms: p53-tg^b, Super p53
• Transgene: Tg(Trp53)bSrn Location: unknown
• Alliance: Tg(Trp53)bSrn page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Trp53)bSrn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Trp53 (MGI:98834)

• Mutation details: The transgene contains a 175 kb murine BAC segment with the centrally located gene of interest. Line b contains two copies of the transgene. (J:80311)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Trp53)bSrn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:80311 Garcia-Cao I, et al., 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 2002 Nov 15;21(22):6225-35
• All: 4 reference(s)