Rheb^tm1.1Yelg
Targeted Allele Detail

Summary

• Symbol: Rheb^tm1.1Yelg
• Name: Ras homolog enriched in brain; targeted mutation 1.1, Ype Elgersma
• MGI ID: MGI:4949062
• Gene: Rheb Location: Chr5:25007821-25047359 bp, - strand Genetic Position: Chr5, 11.93 cM
• Alliance: Rheb^tm1.1Yelg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170999
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced a portion of the 5'UTR, and exon 3 was flanked by loxP sites. Cre-mediated recombination removed the neo cassette and exon 3. The absences of protein expression was confirmed by western blot analysis on E11.5 whole embryo extracts (J:170999)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rheb Mutation: 26 strains or lines available

References

• Original: J:170999 Goorden SM, et al., Rheb is essential for murine development. Mol Cell Biol. 2011 Apr;31(8):1672-8
• All: 2 reference(s)