Grn^tm1.1Far
Targeted Allele Detail

Summary

• Symbol: Grn^tm1.1Far
• Name: granulin; targeted mutation 1.1, Bob Farese
• MGI ID: MGI:4949110
• Synonyms: Grn^tm1.1Cke, Prgn^-
• Gene: Grn Location: Chr11:102321333-102327635 bp, + strand Genetic Position: Chr11, 66.29 cM
• Alliance: Grn^tm1.1Far page

Increased total and phosphorylated TDP-43 in the cytoplasm of thalamic neurons in Grn^tm2.1Far/Grn^tm2.1Far and Grn^tm1.1Far/Grn^tm1.1Far mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170823
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted flanking exons 2 to 13 and a neo cassette was inserted downstream of the polyadenylation signal via homologous recombination. Cre mediated recombination removed exons 2 to 13. Western blot analysis confirmed the absence of protein expression in peritoneal macrophages from homozygous mice. (J:170823)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grn Mutation: 48 strains or lines available

References

• Original: J:170823 Kao AW, et al., A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4441-6
• All: 26 reference(s)