Snx27^tm1Lslo
Targeted Allele Detail

Summary

• Symbol: Snx27^tm1Lslo
• Name: sorting nexin family member 27; targeted mutation 1, Li Shen Loo
• MGI ID: MGI:4949192
• Gene: Snx27 Location: Chr3:94404851-94490023 bp, - strand Genetic Position: Chr3, 40.74 cM, cytoband F2
• Alliance: Snx27^tm1Lslo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171001
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 3. The absence of protein expression was confirmed by western blot analysis on kidney and brain extracts. (J:171001)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snx27 Mutation: 25 strains or lines available

References

• Original: J:171001 Cai L, et al., Deficiency of Sorting Nexin 27 (SNX27) Leads to Growth Retardation and Elevated Levels of N-Methyl-D-Aspartate Receptor 2C (NR2C). Mol Cell Biol. 2011 Apr;31(8):1734-47
• All: 8 reference(s)