Kif5c^tm2Gsn
Targeted Allele Detail

Summary

• Symbol: Kif5c^tm2Gsn
• Name: kinesin family member 5C; targeted mutation 2, Lawrence S B Goldstein
• MGI ID: MGI:4949203
• Synonyms: Kinesin-1C^-
• Gene: Kif5c Location: Chr2:49509310-49664790 bp, + strand Genetic Position: Chr2, 28.68 cM, cytoband C
• Alliance: Kif5c^tm2Gsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170887
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced two exons, which code for amino acid 132 to the first two nucleotides of amino acid 196. The absence of protein expression was confirmed by western blot analysis of brain lysates. (J:170887)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif5c Mutation: 49 strains or lines available

References

• Original: J:170887 Encalada SE, et al., Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles. Cell. 2011 Feb 18;144(4):551-65
• All: 3 reference(s)