Foxo3^mommeR1
Chemically induced Allele Detail

Summary

• Symbol: Foxo3^mommeR1
• Name: forkhead box O3; modifier of murine metastable epialleles, R1
• MGI ID: MGI:4949204
• Synonyms: MommeR1
• Gene: Foxo3 Location: Chr10:42057841-42152691 bp, - strand Genetic Position: Chr10, 22.79 cM
• Alliance: Foxo3^mommeR1 page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Mice carrying Tg(Hba1-Gfp)1Ew were treated with ENU. ENU induced a T to A transition in exon 2 that changes an isoleucine to asparagine in the highly conserved Forkhead domain. Northern and western blot analysis indicate this mutation does not greatly affect mRNA or protein expression. (J:99816, J:170710)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Foxo3 Mutation: 51 strains or lines available

References

• Original: J:170710 Youngson NA, et al., A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice. Mamm Genome. 2011 Apr;22(3-4):235-48
• All: 4 reference(s)