Mir9-2^tm1Sia
Targeted Allele Detail

Summary

• Symbol: Mir9-2^tm1Sia
• Name: microRNA 9-2; targeted mutation 1, Shinichi Aizawa
• MGI ID: MGI:4949252
• Gene: Mir9-2 Location: Chr13:83886933-83887004 bp, + strand Genetic Position: Chr13, 43.68 cM
• Alliance: Mir9-2^tm1Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170671
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 72 nt region encoding the mature microRNA was replaced with a floxed pgk-neo cassette via homologous recombination. Quantitative RT-PCR analysis confirmed the absence of RNA expression and lack of any compensatory increase in Mir9-1 expression in homozygous mice null for both Mir9-2 and Mir9-3. (J:170671)

Expression

In Mice Carrying this Mutation:

165 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir9-2 Mutation: 4 strains or lines available

References

• Original: J:170671 Shibata M, et al., MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. J Neurosci. 2011 Mar 2;31(9):3407-22
• All: 1 reference(s)