Prkn^tm2Tmd
Targeted Allele Detail

Summary

• Symbol: Prkn^tm2Tmd
• Name: parkin RBR E3 ubiquitin protein ligase; targeted mutation 2, Ted M Dawson
• MGI ID: MGI:4949289
• Synonyms: parkin^Flx
• Gene: Prkn Location: Chr17:11059271-12282248 bp, + strand Genetic Position: Chr17, 7.8 cM, cytoband A3.2-A3.3
• Alliance: Prkn^tm2Tmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171058
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 7 was floxed. (J:171058)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkn Mutation: 54 strains or lines available

References

• Original: J:171058 Shin JH, et al., PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease. Cell. 2011 Mar 4;144(5):689-702
• All: 9 reference(s)