Ern1^tm2.1Rjk
Targeted Allele Detail

Summary

• Symbol: Ern1^tm2.1Rjk
• Name: endoplasmic reticulum to nucleus signalling 1; targeted mutation 2.1, Randal J Kaufman
• MGI ID: MGI:4949317
• Synonyms: Ire1alpha^fe
• Gene: Ern1 Location: Chr11:106285476-106378678 bp, - strand Genetic Position: Chr11, 69.14 cM, cytoband E1
• Alliance: Ern1^tm2.1Rjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171230
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 16. A floxed neo cassette was inserted downstream of exon 17. Cre-mediated recombination removed the neo cassette and left exons 16 and 17 floxed. (J:171230)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ern1 Mutation: 58 strains or lines available

References

• Original: J:171230 Zhang K, et al., The unfolded protein response transducer IRE1alpha prevents ER stress-induced hepatic steatosis. EMBO J. 2011 Apr 6;30(7):1357-75
• All: 19 reference(s)