Gnrh1^tm1.1Hjn
Targeted Allele Detail

Summary

• Symbol: Gnrh1^tm1.1Hjn
• Name: gonadotropin releasing hormone 1; targeted mutation 1.1, Horacio J Novaira
• MGI ID: MGI:4949468
• Synonyms: GREKO^-
• Gene: Gnrh1 Location: Chr14:67982717-67986889 bp, + strand Genetic Position: Chr14, 34.66 cM
• Alliance: Gnrh1^tm1.1Hjn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170674
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A self-excising neomycin resistance cassette, containing a mouse testes-specific Ace promoter, cre recombinase and neomycin resistance genes, replaced a fragment between -2806 and -2078 bp that codes for a common element in the promoter. This element has been shown to mediate differential regulation of hypothalamic and ovarian expression. Quantitative RT-PCR analysis of brain and ovary tissue from homozygous female mice found reduced expression in the brain during diestrus and proestrus but increased expression in the ovary during diestrus and proestrus. In homozygous males hypothalamic expression was reduced. (J:170674)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnrh1 Mutation: 11 strains or lines available

References

• Original: J:170674 Novaira HJ, et al., The gonadotropin-releasing hormone cell-specific element is required for normal puberty and estrous cyclicity. J Neurosci. 2011 Mar 2;31(9):3336-43
• All: 1 reference(s)