Cacna1a^tm1.1Sher
Targeted Allele Detail

Summary

• Symbol: Cacna1a^tm1.1Sher
• Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 1.1, Stefan Herlitze
• MGI ID: MGI:4949728
• Synonyms: Cacna1a^Citrine, Cacna1a^tm-Citrine+
• Gene: Cacna1a Location: Chr8:85065268-85366875 bp, + strand Genetic Position: Chr8, 40.95 cM
• Alliance: Cacna1a^tm1.1Sher page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170451
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A cassette, which contained (5' to 3') a loxP site, citrine reporter, duplicate exon 1, second loxP site, neo cassette, and third loxP site, was inserted downstream of exon 1. Cre-mediated recombination removed the neo cassette while the floxed citrine reporter and duplicate exon 1 remain intact. (J:170451)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1a Mutation: 118 strains or lines available

References

• Original: J:170451 Mark MD, et al., Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations. J Neurosci. 2011 Mar 16;31(11):4311-26
• All: 7 reference(s)