Shank3^tm2Gfng
Targeted Allele Detail

Summary

• Symbol: Shank3^tm2Gfng
• Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 2, Guoping Feng
• MGI ID: MGI:4949738
• Synonyms: Shank3B^-, Shank3/F
• Gene: Shank3 Location: Chr15:89383826-89444464 bp, + strand Genetic Position: Chr15, 44.96 cM
• Alliance: Shank3^tm2Gfng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171113
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence from exons 13 through 16, which encode the PDZ domain, was replaced with a neo cassette. The absence of alpha and beta isoform expression and reduced gamma isoform expression were confirmed by western blot analysis on brain extracts. (J:171113)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shank3 Mutation: 85 strains or lines available

References

• Original: J:171113 Peca J, et al., Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature. 2011 Apr 28;472(7344):437-42
• All: 73 reference(s)