Kcnu1^tm1.2Clin
Targeted Allele Detail

Summary

• Symbol: Kcnu1^tm1.2Clin
• Name: potassium channel, subfamily U, member 1; targeted mutation 1.2, Christopher J Lingle
• MGI ID: MGI:4949763
• Gene: Kcnu1 Location: Chr8:26339651-26427967 bp, + strand Genetic Position: Chr8, 14.17 cM, cytoband A3
• Alliance: Kcnu1^tm1.2Clin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171225
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 27, the EGFP, and the neo cassette. The absence of protein expression was confirmed by western blot analysis on testes extracts. (J:171225)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnu1 Mutation: 63 strains or lines available

References

• Original: J:171225 Zeng XH, et al., Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5879-84
• All: 4 reference(s)