Grb2^tm1Lnit
Targeted Allele Detail

Summary

• Symbol: Grb2^tm1Lnit
• Name: growth factor receptor bound protein 2; targeted mutation 1, Lars Nitschke
• MGI ID: MGI:4949889
• Gene: Grb2 Location: Chr11:115534871-115599423 bp, - strand Genetic Position: Chr11, 80.91 cM
• Alliance: Grb2^tm1Lnit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171222
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. (J:171222)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grb2 Mutation: 43 strains or lines available

References

• Original: J:171222 Ackermann JA, et al., Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca(2+) signalling. EMBO J. 2011 Apr 20;30(8):1621-33
• All: 1 reference(s)