Adgra2^tm1.1Bstc
Targeted Allele Detail

Summary

• Symbol: Adgra2^tm1.1Bstc
• Name: adhesion G protein-coupled receptor A2; targeted mutation 1.1, Brad St Croix
• MGI ID: MGI:4949901
• Synonyms: Gpr124^flox
• Gene: Adgra2 Location: Chr8:27575611-27613464 bp, + strand Genetic Position: Chr8, 15.91 cM, cytoband A3
• Alliance: Adgra2^tm1.1Bstc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171226
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT-loxP-neo-FRT-loxP cassette was introduced downstream of exon 1 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:171226)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adgra2 Mutation: 43 strains or lines available

References

• Original: J:171226 Cullen M, et al., GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64
• All: 6 reference(s)