Ccn2^tm1.1Alea
Targeted Allele Detail

Summary

• Symbol: Ccn2^tm1.1Alea
• Name: cellular communication network factor 2; targeted mutation 1.1, Andrew Leask
• MGI ID: MGI:4949916
• Synonyms: CCN2^fl, Ctgf^flox
• Gene: Ccn2 Location: Chr10:24471340-24474581 bp, + strand Genetic Position: Chr10, 11.84 cM, cytoband A3-B1
• Alliance: Ccn2^tm1.1Alea page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171300
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP iste was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 4. Flp-mediated recombination removed the neo cassette. (J:171300)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccn2 Mutation: 29 strains or lines available

References

• Original: J:171300 Liu S, et al., CCN2 is required for bleomycin-induced skin fibrosis in mice. Arthritis Rheum. 2011 Jan;63(1):239-46
• All: 21 reference(s)