Ush1g^tm1.2Ugds
Targeted Allele Detail

Summary

• Symbol: Ush1g^tm1.2Ugds
• Name: USH1 protein network component sans; targeted mutation 1.2, Unite de Genetique des Deficits Sensoriels
• MGI ID: MGI:4950014
• Synonyms: Ush1g^-
• Gene: Ush1g Location: Chr11:115206018-115212867 bp, - strand Genetic Position: Chr11, 80.84 cM
• Alliance: Ush1g^tm1.2Ugds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171218
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette leaving and cre mediated recombination removed exon 2. (J:171218)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ush1g Mutation: 16 strains or lines available

References

• Original: J:171218 Caberlotto E, et al., Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5825-30
• All: 6 reference(s)