Kdm2b^tm1Nobu
Targeted Allele Detail

Summary

• Symbol: Kdm2b^tm1Nobu
• Name: lysine (K)-specific demethylase 2B; targeted mutation 1, Nobuaki Yoshida
• MGI ID: MGI:4950034
• Gene: Kdm2b Location: Chr5:123008727-123127333 bp, - strand Genetic Position: Chr5, 62.63 cM, cytoband F
• Alliance: Kdm2b^tm1Nobu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171291
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 7 and 8. The absence of long form protein expression and presence of short form protein expression were confirmed by western blot analysis on thymus extracts. (J:171291)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm2b Mutation: 220 strains or lines available

References

• Original: J:171291 Fukuda T, et al., Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. Mol Cell Neurosci. 2011 Mar;46(3):614-24
• All: 1 reference(s)