Ntrk3^tm1.1Tes
Targeted Allele Detail

Summary

• Symbol: Ntrk3^tm1.1Tes
• Name: neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1.1, Lino Tessarollo
• MGI ID: MGI:4950053
• Synonyms: TrkC.T1^-
• Gene: Ntrk3 Location: Chr7:77825711-78228865 bp, - strand Genetic Position: Chr7, 44.01 cM
• Alliance: Ntrk3^tm1.1Tes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171397
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 13b and a floxed ura/neomycin selection cassette was placed downstream of exon 14b. Cre expression results in removal of 2.5kb of sequence including both exons 13b and 14b. The deleted locus can no longer express the TrkC.T1 isoform. Full length product is expressed at a level of 1.6X normal however. (J:171397)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk3 Mutation: 67 strains or lines available

References

• Original: J:171397 Bai Y, et al., In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death. Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6639-51
• All: 2 reference(s)