Otof^tm1.1Erei
Targeted Allele Detail

Summary

• Symbol: Otof^tm1.1Erei
• Name: otoferlin; targeted mutation 1.1, Ellen Reisinger
• MGI ID: MGI:4950055
• Gene: Otof Location: Chr5:30524406-30619276 bp, - strand Genetic Position: Chr5, 16.48 cM, cytoband B1
• Alliance: Otof^tm1.1Erei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171203
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced exons 14 and 15. Cre-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by immunohistochemistry on cochlea samples. (J:171203)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otof Mutation: 110 strains or lines available

References

• Original: J:171203 Reisinger E, et al., Probing the Functional Equivalence of Otoferlin and Synaptotagmin 1 in Exocytosis. J Neurosci. 2011 Mar 30;31(13):4886-4895
• All: 8 reference(s)